載脂蛋白M抗體*
『別名』Apo M; Apo-M; Apolipoprotein M; ApoM; APOM_HUMAN; G3A; HSPC336; MGC22400; NG20; NG20 like protein; Protein G3a.
『濃度』1mg/1ml
『規格』0.2ml/200μg
『抗體來源』Rabbit
『克隆類型』polyclonal
『交叉反應』Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep
『產品類型』一抗
『研究領域』腫瘤 細胞生物 新陳代謝
『蛋白分子量』predicted molecular weight: 21kDa
『性狀』Lyophilized or Liquid
『免疫原』KLH conjugated synthetic peptide derived from human ApoM/Apolipoprotein M
『亞型』IgG
『純化方法』affinity purified by Protein A
『儲存液』Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
『產品應用』WB=1:100-500 ELISA=1:500-1000 載脂蛋白M抗體* IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500
（石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
『保存條件』Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
『產品介紹』Apolipoproteins are protein components of plasma lipoproteins. ApoM (Apolipoprotein M), also known as protein G3a, is a member of the Lipocalin family of proteins. ApoM is exclusively expressed in kidney tubular epithelial cells and liver hepatocytes. Mature ApoM retains its signal peptide, which acts as a hydrophobic anchor, and contains a structurally conserved eight stranded antiparallel ∫ barrel which binds retinol and retinoic acid. ApoM may play a key role in reverse cholesterol transport. It mainly associates with high density lipoprotein (HDL) and to a lesser extent with triglyceride-rich lipoprotein (TGRLP) and low-density lipoprotein (LDL). ApoM is important for the pre∫-HDL formation. Pre∫-HDL is an important acceptor of peripheral cellular cholesterol. The concentration of ApoM in plasma strongly correlates with total cholesterol. Low concentrations of ApoM in plasma is associated with diabetes.
Function : Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.
Subcellular Location : Secreted. Present in high density lipoprotein (HDL) and to a lesser extent in triglyceride-rich lipoproteins (TGRLP) and low density lipoproteins.
Tissue Specificity : Plasma protein. Expressed in liver and kidney.
Similarity : Belongs to the calycin superfamily. Lipocalin family. Highly divergent.
Database links : UniProtKB/Swiss-Prot: O95445.2
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