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閱讀:284發布時間:2013-7-23
雌激素受體α抗體,Anti-ER α antibody抗體Background: Estrogen and progesterone receptor are members of a family of transcription factors that are regulated by the binding of their cognate ligands. The interaction of hormone-bound estrogen receptors with estrogen responsive elements(EREs) alters transcription of ERE-containing genes. The carboxy terminal region of the estrgen receptor contains the ligand binding domain, the amino terminus serves as the transactivation domain, and the DNA binding domain is centrally located. Two forms of estrogen receptor have been identified, ER Alpha and ER Beta. ER Alpha and ER Beta have been shown to be differentially activated by various ligands. The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (hPR-A and hPR-B), which arise from alternative splicing. In most cells, hPR-B functions as a transcriptional activator of progesterone-responsive gene, whereas hPR-A function as a transcriptional inhibitor of all steroid hormone receptors.
雌激素受體α抗體,Anti-ER α antibody抗體Specificity :
Anti-ER α is a rabbit polyclonal antibody unconjugated
specific for ERα of human, rat,mo
use for western blotting,elisa,immunoprecipitation and immunohistochemistry
Protein G affinity chromatography purification, purity :>95%
Isotype: IgG
mol wt: 66kDa
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